CDK4
cyclin-dependent kinase 4
别名:
CMM3, PSK-J3
物种:
Human CDK4 (1019), Mouse Cdk4 (12567), Rat Cdk4 (94201), naked mole-rat Cdk4 (101702608), domestic guinea pig Cdk4 (100717960), cow CDK4 (510618), Domestic Rabbit CDK4 (100009039), Zebrafish cdk4 (777730), domestic cat CDK4 (101097903), dog CDK4 (481131) ...展开
UniProtKB ID:
基因ID:
- Human(1019) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
- Mouse(12567) cyclin-dependent kinase 4
- Rat(94201) cyclin-dependent kinase 4
- naked mole-rat(101702608) cyclin-dependent kinase 4
- domestic guinea pig(100717960) cyclin-dependent kinase 4
- cow(510618) cyclin-dependent kinase 4
- Domestic Rabbit(100009039) cyclin-dependent kinase 4
- Zebrafish(777730) cyclin-dependent kinase 4
- domestic cat(101097903) cyclin-dependent kinase 4
- dog(481131) cyclin-dependent kinase 4
- sheep(100144756) cyclin-dependent kinase 4
- fruit fly(36854) Cyclin-dependent kinase 4
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Antibodies
货号
说明
物种反应性
应用
Anti-Phospho-CDK4-T172 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
western blot
Anti-CDK4 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-CDK4 (AB1) antibody produced in rabbit, IgG fraction of antiserum,
物种反应性
human
应用
western blot
Monoclonal Anti-CDK4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL8102, purified immunoglobulin, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-CDK4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Small Molecule - Inhibitor
Proteins
货号
说明
物种
CDK4/活性人细胞周期蛋白 D1, recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE),
物种
human
CDK4/Cyclin D1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
CDK4/CyclinD3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human