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安全信息

U6508

Sigma-Aldrich

UCN-01

≥97% (HPLC), powder

别名:

KW-2401

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About This Item

经验公式（希尔记法）:
C28H26N4O4
CAS号:
112953-11-4
分子量:
482.53
MDL编号:
MFCD26960886
UNSPSC代码:
12352200
PubChem化学物质编号:
24724639
NACRES:
NA.77

质量水平

100

方案

≥97% (HPLC)

表单

powder

旋光性

[α]20/D 130 to 160°, c = 0.2 in DMSO

储存条件

protect from light

颜色

light yellow

溶解性

DMSO: >5 mg/mL
H2O: insoluble

储存温度

2-8°C

SMILES字符串

[H][C@@]1(C[C@@H](NC)[C@H]2OC)N3C4=C(N([C@@]2(C)O1)C5=C6C=CC=C5)C6=C7C(C(N[C@@H]7O)=O)=C4C8=C3C=CC=C8

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1

InChI key

PBCZSGKMGDDXIJ-HQCWYSJUSA-N

基因信息

human ... CDK2(1017) , CDK4(1019) , CDK6(1021) , CHEK1(1111) , PDPK1(5170) , PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584) , PRKCQ(5588) , PRKCZ(5590) , PRKD1(5587) , PRKD3(23683)

应用

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

生化/生理作用

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

特点和优势

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

制备说明

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000291018
0000291018
0000291019
0000291019
0000146792

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