所有图片(1)
About This Item
经验公式（希尔记法）:
C15H18N6O
CAS号:
分子量:
298.34
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
DMSO: 20 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc12
InChI
1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20)
InChI key
GTVPOLSIJWJJNY-UHFFFAOYSA-N
基因信息
human ... CDC2(983) , CDK2(1017) , CDK3(1018) , CDK4(1019) , CDK5(1020) , CDK6(1021) , CDK7(1022) , CDK8(1024) , CDK9(1025) , CDKN1A(1026) , CDKN1B(1027) , CDKN1C(1028) , CDKN2A(1029) , CDKN2B(1030) , CDKN2C(1031) , CDKN2D(1032) , CDKN3(1033)
rat ... Prkca(24680)
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
R T Abraham et al.
Biology of the cell, 83(2-3), 105-120 (1995-01-01)
Olomoucine (2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine) has been recently described as a competitive inhibitor (ATP-binding site) of the cell cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/MAP-kinase. The unusual specificity of this compound towards cell
Brajendra K Tripathi et al.
Molecular vision, 14, 542-549 (2008-04-04)
To investigate the effect of the Cdk5 inhibitor olomoucine on corneal debridement wound healing in vivo. Corneal debridement wounds of 1.5 mm were made on the ocular surface of CD-1 mice. A 20 microl drop of 15 microM olomoucine in
J Veselý et al.
European journal of biochemistry, 224(2), 771-786 (1994-09-01)
While testing purines related to the non-specific protein kinase inhibitors N6-dimethylaminopurine and N6-(delta 2-isopentenyl)adenine as potential inhibitors of the p34cdc2/cyclin B kinase, we discovered a compound with high specificity, 2-(2-hydroxyethylamino)-6- benzylamino-9-methylpurine (olomoucine). Kinetic analysis of kinase inhibition reveals that olomoucine
Wei Mao et al.
Journal of experimental & clinical cancer research : CR, 31, 49-49 (2012-05-25)
Gastrokine-1 (GKN1), a secreted protein, is specifically expressed in gastric mucosa to protect and maintain the integrity of gastric epithelium. The present study investigated differential expression of GKN1 in normal, precancerous, and cancerous gastric tissues, and explored the biological functions
Takuro Tojima et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7165-7178 (2014-05-23)
Extracellular molecular cues guide migrating growth cones along specific routes during development of axon tracts. Such processes rely on asymmetric elevation of cytosolic Ca(2+) concentrations across the growth cone that mediates its attractive or repulsive turning toward or away from
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