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Merck
CN

C8093

Anti-Connexin 43 Antibody

mouse monoclonal, CXN-6

别名:

小鼠单克隆抗体

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
Conjugate:
unconjugated
Clone:
CXN-6, monoclonal
Application:
immunocytochemistry
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (frozen sections)
indirect ELISA
microarray
western blot
Species reactivity:
rat, hamster, bovine, mouse, human
Citations:
47
Technique(s):
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:8,000-1:16.000 using mouse whole brain extract
Uniprot accession no.:
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产品名称

单克隆抗-连接蛋白-43 小鼠抗, clone CXN-6, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CXN-6, monoclonal

mol wt

antigen 43 kDa

contains

15 mM sodium azide

species reactivity

rat, hamster, bovine, mouse, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (frozen sections): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1:8,000-1:16.000 using mouse whole brain extract

isotype

IgM

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... GJA1(2697), GJA1P1(2698)
mouse ... Gja1(14609)
rat ... Gja1(24392)

Application

小鼠源抗连接蛋白-43单克隆抗体用于:
  • 荧光免疫染色,
  • 免疫印迹
  • ,免疫细胞化学
  • ,免疫亲和柱的制备

Biochem/physiol Actions

单克隆抗连接蛋白-43与连接蛋白-43发生特异性反应。已观察到与人,牛,仓鼠,大鼠和小鼠连接蛋白43的反应性。
连接蛋白43(Cx43)基因的突变导致眼齿指发育不良的多效性表型。连接蛋白43参与成熟T细胞的增殖和分化。它还参与细胞因子的分泌和制造。它有助于从糖酵解性胰腺导管腺癌细胞释放乳酸盐。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

43 kDa连接蛋白蛋白(连接蛋白43,Cx43)属于连接蛋白的A型(II组)亚家族。 它在大多数组织中表达,即使在各种细胞类型中表达模式可能不同。 例如,在大脑中,它存在于星形胶质细胞,室管膜和软脑膜中,但不存在于神经元,少突胶质细胞和松果体细胞中。在肝脏中,它存在于Ito细胞中,但不存在于肝细胞中。
单克隆抗-连接蛋白-43(小鼠IgM亚型)抗体来自于免疫小鼠骨髓瘤细胞和脾细胞相互融合而产生的CXN-6杂交瘤。连接蛋白43(Cx43)又称GJA1(间隙连接蛋白α1)。连接蛋白分子的结构包括一个胞质N端区域,四个跨膜结构域,两个胞外环和一个不同长度的C端胞质尾。

Immunogen

合成连接蛋白-43肽(362-381)。

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存储类别

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Multimodal tumor suppression by miR-302 cluster in melanoma and colon cancer
Maadi H, et al.
The International Journal of Biochemistry & Cell Biology, 81, 121-132 (2016)
Daniel J Jagger et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(48), 15851-15860 (2014-11-28)
The loss of auditory hair cells triggers repair responses within the population of nonsensory supporting cells. When hair cells are irreversibly lost from the mammalian cochlea, supporting cells expand to fill the resulting lesions in the sensory epithelium, an initial
Faten Shaeib et al.
Reproductive sciences (Thousand Oaks, Calif.), 23(4), 498-507 (2015-10-16)
We investigated the ability of reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)), hydroxyl radical ((·)OH), and hypochlorous acid (HOCl), to overcome the defensive capacity of cumulus cells and elucidate the mechanism through which ROS differentially deteriorate oocyte quality.
Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123)
Axelsen LN, et al.
Journal of Molecular and Cellular Cardiology, 40(6), 790-798 (2006)
Up-regulation of gap junction in peripheral blood T lymphocytes contributes to the inflammatory response in essential hypertension
Ni X, et al.
Testing, 12(9) (2017)

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