Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages.

Photocytotoxicity of platinum(IV)-chloride surface modified TiO2 irradiated with visible light against murine macrophages.

Journal of photochemistry and photobiology. B, Biology (2008-06-17)

Agnieszka Jańczyk, Agnieszka Wolnicka-Głubisz, Krystyna Urbanska, Grazyna Stochel, Wojciech Macyk

ABSTRACT

Phototoxicity of titanium dioxide modified with platinum(IV)-chloride complexes, [TiO2/PtCl4], irradiated with visible light was tested on murine macrophage cell line (RAW 264.7) in vitro. Presence of antioxidants such as alpha-tocopherol or beta-carotene during photodynamic treatment significantly increased cells viability. Our results indicate that observed cell death induced by [TiO2/PtCl4] was due to photogeneration of reactive species.

MATERIALS

Product Number

Brand

Product Description

379840

Sigma-Aldrich

Platinum(IV) chloride, ≥99.99% trace metals basis

520640

Sigma-Aldrich

Platinum(IV) chloride, ≥99.9% trace metals basis

206113

Sigma-Aldrich

Platinum(IV) chloride, 96%