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Hydroxychloroquine sulfate

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
747-36-4
Molecular Weight:
433.95
EC Number:
212-019-3
MDL number:
MFCD00078203
UNSPSC Code:
41116107
PubChem Substance ID:
329750122
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

USP

API family

hydroxychloroquine

packaging

pkg of 200 mg

manufacturer/tradename

USP

storage condition

protect from light

color

white to off-white

pH

3.5-5.5 (1% in aqueous solution, pH <6.0)

mp

388.4 °F (198°C; 240°C)

solubility

chloroform: practically insoluble
ethanol: practically insoluble
ether: practically insoluble
water: soluble

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Gene Information

human ... TLR7(51284) , TLR9(54106)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Hydroxychloroquine Sulfate is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.

Application

Hydroxychloroquine sulfate USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard and system suitability solutions for assay, impurity analysis, and performance test, according to the given below monographs of United States Pharmacopeia (USP):
  • Hydroxychloroquine Sulfate Tablets
  • Hydroxychloroquine Sulfate
  • Chloroquine Phosphate

Biochem/physiol Actions

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hydroxychloroquine Sulfate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2) (2021)
Hydroxychloroquine Sulfate Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(3) (2022)
Chloroquine Phosphate
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(3), 959-959 (2020)
Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
Jacques-Eric Gottenberg et al.
JAMA, 312(3), 249-258 (2014-07-17)
Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome. However, evidence regarding its efficacy is limited. To evaluate the efficacy of hydroxychloroquine
View All Related Papers

Protocols

Chloroquine Phosphate HPLC Assay & Impurity Profiling

Chloroquine Phosphate HPLC Assay meets system suitability criteria with good resolution, reproducibility, and sensitivity.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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