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USP

Flurbiprofen

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
(±)-2-Fluoro-α-methyl-4-biphenylacetic acid, L-790,330
Linear Formula:
C6H5C6H3(F)CH(CH3)CO2H
CAS Number:
5104-49-4
Molecular Weight:
244.26
MDL number:
MFCD00079303
UNSPSC Code:
41116107
PubChem Substance ID:
329749901
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

flurbiprofen

manufacturer/tradename

USP

mp

110-112 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2

InChI

1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)

InChI key

SYTBZMRGLBWNTM-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Flurbiprofen USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard, standard stock, and system suitability solution during the assay, impurity analysis, and performance test by using liquid chromatography coupled with UV detector according to the given below monographs of United States Pharmacopeia (USP): 
  • Flurbiprofen Tablets
  • Flurbiprofen Sodium
  • Flurbiprofen Sodium Ophthalmic Solution

Biochem/physiol Actions

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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PHR1499

Flurbiprofen, Pharmaceutical Secondary Standard; Certified Reference Material

1285760

Flurbiprofen Related Compound A, United States Pharmacopeia (USP) Reference Standard

1285807

Flurbiprofen sodium, United States Pharmacopeia (USP) Reference Standard

BP574

Flurbiprofen sodium, British Pharmacopoeia (BP) Reference Standard

BP046

2-(Biphenyl-4-yl)propionic acid, British Pharmacopoeia (BP) Reference Standard

BP681

4-Acetyl-2-fluorobiphenyl, British Pharmacopoeia (BP) Reference Standard

PHR2710

Flurbiprofen Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard

PHR2711

Flurbiprofen Sodium, certified reference material, pharmaceutical secondary standard

Y0002271

Flurbiprofen for peak identification, CRS, European Pharmacopoeia (EP) Reference Standard

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Flurbiprofen Sodium
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1981-1981 (2020)
Flurbiprofen Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1980-1980 (2015)
Flurbiprofen Sodium Ophthalmic Solution
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 48(3), 1982-1982 (2013)

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