1205003
USP
Diltiazem hydrochloride
United States Pharmacopeia (USP) Reference Standard
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All Photos(1)
Synonym(s):
(+)-cis-Diltiazem hydrochloride, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401
Empirical Formula (Hill Notation):
C22H26N2O4S · HCl
CAS Number:
Molecular Weight:
450.98
Beilstein:
4228706
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
pharmaceutical primary standard
API family
diltiazem
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
SMILES string
Cl.COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O
InChI
1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1
InChI key
HDRXZJPWHTXQRI-BHDTVMLSSA-N
Gene Information
human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779)
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General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
- Exploring the Effectiveness of Carboxymethylated and Crosslinked Albizia procera Gum in Diltiazem Hydrochloride Matrix Tablets: A Comparative Analysis. This study investigates the potential of carboxymethylated and crosslinked Albizia procera gum for use in sustained-release matrix tablets containing Diltiazem hydrochloride, highlighting its viability in pharmaceutical applications (Mukherjee S, Khanam J, 2024).
- Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions. While primarily focused on gallic acid, this review mentions Diltiazem hydrochloride in the context of drug interactions and its implications in food safety and health (Xiang Z et al., 2024).
- Dual stimuli-responsive and sustained drug delivery NanoSensoGel formulation for prevention of cisplatin-induced ototoxicity. This research presents a novel NanoSensoGel that could be adapted for Diltiazem hydrochloride, enhancing drug delivery efficiency in clinical settings (Thakur NS et al., 2024).
- A novel potentiometric sensor based on ZnO decorated polyaniline/coal nanocomposite for diltiazem determination. This study develops a new sensor for the precise measurement of Diltiazem levels in pharmaceutical formulations, which is crucial for quality control and regulatory compliance (El Sayed GA et al., 2023).
- The Effect of Topical Nifedipine versus Diltiazem on the Acute Anal Fissure: A Randomized Clinical Trial. This clinical trial evaluates the effectiveness of Diltiazem hydrochloride in treating acute anal fissures, providing evidence of its beneficial applications in proctological disorders (Momayez Sanat Z et al., 2023).
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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Product No.
Description
Pricing
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Diltiazem hydrochloride.
B F McGraw
Drug intelligence & clinical pharmacy, 16(5), 366-370 (1982-05-01)
Jaime A Foushee et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 72(6), 483-486 (2015-03-05)
The physical compatibility of cisatracurium with selected drugs during simulated Y-site administration was studied. Study drugs were selected based on the lack of physical compatibility data with cisatracurium and their use in intensive care units. Test admixtures were prepared by
K Adibkia et al.
Drug research, 64(4), 203-207 (2013-09-13)
The aim of this study was to design and evaluate diltiazem hydrochloride controlled porosity osmotic pump (CPOP) system employing a new coating technique named the micro suspension coating method. In this method the fast dissolving pore formers were suspended in
[Diltiazem hydrochloride: synthetic and pharmacological studies and development].
K Abe et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 108(8), 716-732 (1988-08-01)
B J McAuley et al.
Pharmacotherapy, 2(3), 121-133 (1982-05-01)
Diltiazem, a calcium channel blocking agent, has potent cardiovascular effects that are directly related to its influence on vascular smooth muscle, ventricular myocardium, and specialized conducting tissue. It causes coronary and peripheral vasodilation, has a negative chronotropic and dromotropic effect
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