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About This Item
Empirical Formula (Hill Notation):
C20H25ClN2O5 · C6H5SO3H
CAS Number:
Molecular Weight:
567.05
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
pharmaceutical primary standard
API family
amlodipine
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
OS(=O)(=O)c1ccccc1.CCOC(=O)C2=C(COCCN)NC(C)=C(C2c3ccccc3Cl)C(=O)OC
InChI
1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)
InChI key
ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
General description
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
Application
Amlodipine besylate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Amlodipine and Atorvastatin Tablets
- Amlodipine and Benazepril Hydrochloride Capsules
- Amlodipine and Olmesartan Medoxomil Tablets
- Amlodipine and Valsartan Tablets
- Amlodipine Besylate
- Amlodipine Besylate Tablets
- Amlodipine Compounded Oral Suspension
Biochem/physiol Actions
Amlodipine besylate is an L-type calcium channel blocker.
Amlodipine is an L-type calcium channel blocker. Amlodipine belongs to a class of cardiovascular drugs, which act at the voltage gated calcium channel of the CaV1, or L-type, class. Amlodipine also has antihypertensive and antianginal effects. Its activity resides mainly in the (-)-isomer. Amlodipine inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Other Notes
Sales restrictions may apply.
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Hazard Classifications
Acute Tox. 4 Oral
signalword
Warning
hcodes
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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C Venkata S Ram
Expert review of cardiovascular therapy, 9(1), 9-19 (2010-12-21)
Hypertension is an increasingly prevalent cardiovascular risk factor associated with high rates of morbidity and mortality. Lowering blood pressure (BP) to recommended levels reduces the risk of hypertension-associated cardiovascular events. Despite current treatment options and recommendations, the BP of many
Rishi Puri et al.
Journal of the American College of Cardiology, 65(13), 1273-1282 (2015-04-04)
Statins can regress coronary atheroma and lower clinical events. Although pre-clinical studies suggest procalcific effects of statins in vitro, it remains unclear if statins can modulate coronary atheroma calcification in vivo. This study compared changes in coronary atheroma volume and calcium indices
Amlodipine besylate.
Gennady Ananchenko et al.
Profiles of drug substances, excipients, and related methodology, 37, 31-77 (2012-04-04)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 1029501-350MG | 04061838670069 |