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Retinyl acetate

analytical standard

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Synonym(s):
Retinol acetate, Vitamin A acetate
Empirical Formula (Hill Notation):
C22H32O2
CAS Number:
127-47-9
Molecular Weight:
328.49
Beilstein:
1915439
EC Number:
204-844-2
MDL number:
MFCD00019413
UNSPSC Code:
12164500
PubChem Substance ID:
24870469

grade

analytical standard

Quality Level

100

CofA

current certificate can be downloaded

feature

standard type fat soluble vitamin

packaging

ampule of 100 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

57-58 °C

application(s)

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

format

neat

storage temp.

-10 to -25°C

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(C)=O)C(C)(C)CCC1

InChI

1S/C22H32O2/c1-17(9-7-10-18(2)14-16-24-20(4)23)12-13-21-19(3)11-8-15-22(21,5)6/h7,9-10,12-14H,8,11,15-16H2,1-6H3/b10-7+,13-12+,17-9+,18-14+

InChI key

QGNJRVVDBSJHIZ-QHLGVNSISA-N

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General description

Retinyl acetate is a naturally occurring long-chain fatty acid ester of retinol (Vitamin A). Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard.

Application

The analytical standard can also be used as follows:
  • Simultaneous determination of nine major fat-soluble vitamins― retinyl acetate, retinyl palmitate, retinol, α-tocopherol, α-tocopheryl acetate, cholecalciferol, ergocalciferol, phylloquinone, menaquinone in various commercial food product samples by supercritical fluid chromatography combined with mass spectrometric detection
  • Optimization of a supercritical fluid chromatographic method (SFC) for the simultaneous estimation of fat-soluble vitamins (FSVs) in hemp seed oil and waste fish oil samples, in combination with a diode array detector (DAD)
  • High-performance liquid chromatographic (HPLC) separation and quantification of β-carotene and vitamin A and E esters in infant formulae samples with fluorescence detection (FLD)
  • Analysis of cooking oil samples for the determination of fat-soluble vitamins and carotenoids using an ultra-performance convergence chromatography (UPC2) method
  • Multi-residue estimation of vitamin A and its derivatives in seven cosmetic product samples by liquid chromatography coupled with UV detection

Other Notes

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360D,H413

Hazard Classifications

Aquatic Chronic 4 - Repr. 1B

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ling Zhang et al.
Nature, 464(7291), 1058-1061 (2010-03-30)
Cancer chemoprevention uses natural, synthetic, or biological substances to reverse, suppress, or prevent either the initial phase of carcinogenesis or the progression of neoplastic cells to cancer. It holds promise for overcoming problems associated with the treatment of late-stage cancers.
Avash J Singh et al.
Pediatric research, 67(6), 619-623 (2010-03-11)
Chronic lung disease (CLD) is a major cause of long-term morbidity in extremely LBW infants with respiratory distress syndrome. Parenteral vitamin A administration decreases the risk of CLD. We tested the hypothesis that intratracheal vitamin A administration with surfactant is
Sunatda Arayachukeat et al.
International journal of pharmaceutics, 404(1-2), 281-288 (2010-11-26)
Retinyl acetate (RA) loaded polymeric nanoparticle (NP) carriers were prepared using two different single polymers, ethyl cellulose (EC) and poly (ethylene glycol)-4-methoxycinnamoylphthaloylchitosan (PCPLC). The stability of RA to aqueous solution and UVA light was significantly improved when encapsulated with PCPLC
Emmanuel K Aklamati et al.
The Journal of nutrition, 140(9), 1588-1594 (2010-07-28)
A survey indicated that high-dose vitamin A (HD-VA) supplements had no apparent effect on vitamin A (VA) status, assessed by serum retinol concentrations, of Zambian children lt 5 y of age. To explore possible reasons for the lack of response
Guangwen Tang et al.
The American journal of clinical nutrition, 89(6), 1776-1783 (2009-04-17)
Genetically engineered "Golden Rice" contains up to 35 microg beta-carotene per gram of rice. It is important to determine the vitamin A equivalency of Golden Rice beta-carotene to project the potential effect of this biofortified grain in rice-consuming populations that
View All Related Papers

Protocols

HPLC Analysis of Vitamins, Fat Soluble (A and E), on SUPELCOSIL™ LC-18

Separation of δ-Tocopherol, analytical standard; Retinyl acetate; (+)-γ-Tocopherol; α-Tocopherol, ≥95.5%; Retinol; Vitamin A (acetate), meets USP testing specifications.

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