Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

T5425

Sigma-Aldrich

Transforming Growth Factor-β3 human

TGF-β3, recombinant, expressed in baculovirus infected Sf21 cells, powder, suitable for cell culture

Synonym(s):

hTGF-β3, TGF-β3

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

MDL number:
MFCD00213054
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

Assay

≥97% (SDS-PAGE)

form

powder

potency

0.01-0.09 ng/mL ED50/EC50

quality

endotoxin tested

mol wt

predicted mol wt ~25 kDa

packaging

pkg of 2 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<0.01 EU/μg

UniProt accession no.

P10600

storage temp.

−20°C

Gene Information

human ... TGFB3(7043)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

The TGFβ3 (transforming Growth Factor-β3) gene is mapped to human chromosome 14q24.3.

Application

Transforming Growth Factor-β3 human has been used to study the role of TGF-β3 in healing tendon-to-bone insertion and in chondrogenic differentiation.

Biochem/physiol Actions

TGF-β (transforming growth factor-β3) isoforms are significantly involved in inducing inflammatory responses. It is associated with vascular diseases, wound healing and ameliorating effect in venous leg ulcer. TGF-β3 has an antagonistic effect on TGF-β1 and reduces the degree of collagen type I deposition and fibroblast differentiation. As a result TGF-β3 might lead to ulcer chronicity due to hindered myofibroblasts formation. TGF-β is a key player in tumor formation and progression. Increased TGF-β3 expression is observed in cancer and adipose tissue fibrosis. TGF-β3 is crucial in tissue regeneration and scarless tissue repair.
TGF-β3 is less prevalent in natural expression than either TGF-β1 or TGF-β2, but it is the most abundant mRNA expressed in chick embryos. It is also expressed in human umbilical cord, in a variety of mesenchymal cells of human and rodent origin, and in several human carcinoma cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 50 μg bovine serum albumin per 1 μg of cytokine.

Analysis Note

The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Differential expression of TGF isoforms in breast cancer highlights different roles during breast cancer progression.
Hachim MY, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 40(1) (2018)
Adipose tissue fibrosis in human cancer cachexia: the role of TGFβ pathway
Alves MJ, et al.
BMC Cancer, 17: 190 (2017)
Roberts, A., and Sporn, M. et al.
Peptide Growth Factors and their Receptors I, 419-472 (1991)
Chondrogenic Differentiation of Menstrual Blood-Derived Stem Cells on Nanofibrous Scaffolds
Kazemnejad S, et al.
Methods in Molecular Biology, 149-169 (2013)
The role of transforming growth factor β isoforms in tendon-to-bone healing.
Kim HM, et al.
Connective tissue research, ;52(2), 87-98 (2011)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service