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Key Documents

Safety Information

SRP6155

Sigma-Aldrich

BMP-2 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Synonym(s):

BMP-2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A

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100 ML
CN¥528.15

CN¥528.15

Available to ship onApril 25, 2025Details

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100 ML
CN¥528.15

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

CN¥528.15

Available to ship onApril 25, 2025Details

biological source

human

recombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

form

lyophilized

potency

20-100 ng/mL ED50

mol wt

30-38 kDa (homodimer, glycosylated)

packaging

pkg of 10 μg

technique(s)

cell culture | mammalian: suitable

NCBI accession no.

P12643

shipped in

dry ice

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Giemsa Stain, Modified Solution (for the staining (of cellular blood components and blood parasites))

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Giemsa Stain, Modified Solution

M’Fadyean Stain Solution suitable for microbiology

44378

M′Fadyean Stain Solution

Nigrosin Stain solution suitable for microscopy

43925

Nigrosin Stain solution

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

technique(s)

microbe id | staining: suitable

suitability

fungi, yeasts, parasites

suitability

Chlamydia spp., Histoplasma spp., Plasmodium spp., Trichomonas spp., bacteria, protozoa, spirochetes

suitability

Bacillus spp., Corynebacterium spp.

suitability

Bacillus spp., Corynebacterium spp.

fluorescence

λex 423-443 nm in 0.1 M phosphate pH 7.0

fluorescence

-

fluorescence

-

fluorescence

-

color

blue to very dark blue

color

-

color

-

color

-

form

liquid

form

-

form

liquid

form

liquid

application(s)

food and beverages
hematology
histology, microbiology

application(s)

-

application(s)

diagnostic assay manufacturing
hematology
histology, microbiology

application(s)

diagnostic assay manufacturing
hematology
histology

General description

BMP2 (bone morphogenetic protein 2) belongs to the transforming growth factor-β (TGFβ) superfamily. BMP-2 is expressed in a variety of tissues such as lung, spleen, brain, liver, prostate ovary, and small intestine.[1] BioVision′s BMP-2 is produced in a serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media and other applications.BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

Application

BMP-2 human has been used to study the biological role of it on adult renal progenitor cells under in vitro and in vivo conditions.[2]

Biochem/physiol Actions

BMPs (bone morphogenetic proteins) promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues.[3] During bone repair, BMP-2 controls the expression of Runt-related transcription factor 2 (Runx2) and Osterix (Osx), thereby enhancing migration, proliferation and osteogenic differentiation of mesenchymal stem cells.[4] In addition to its osteogenic activity, BMP-2 also plays an important role in cardiac morphogenesis.[5]

Physical form

Lyophilized from a solution of 50 mM sodium acetate, pH 4.5, with 50 mM NaCl.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    6K19L64440
    9A136444

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    Vera Hintze et al.
    Biomacromolecules, 15(8), 3083-3092 (2014-07-17)
    Sulfated glycosaminoglycans (GAGs) can direct cellular processes by interacting with proteins of the extracellular matrix (ECM). In this study we characterize the interaction profiles of chemically sulfated hyaluronan (HA) and chondroitin sulfate (CS) derivatives with bone morphogenetic protein-2 (BMP-2) and
    Ivo Dumic-Cule et al.
    International orthopaedics, 38(9), 1979-1985 (2014-07-18)
    Bone morphogenetic protein (BMP)-2 and -7 are used in patients with long-bone fractures, nonunions and spinal fusions. It is unknown whether their potential systemic bioavailability following local bone administration might affect skeletal metabolism. To answer this question, we examined effects
    Rick Visser et al.
    Tissue engineering. Part A, 20(1-2), 34-44 (2013-07-19)
    Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of BMPs in combination with collagen type I formulations have to
    BMP-2 induces a profibrotic phenotype in adult renal progenitor cells through Nox4 activation.
    Simone S, et al.
    American Journal of Physiology: Renal Physiology, 303, F23-F34 (2012)
    Nam Hee Kim et al.
    Biomaterials, 35(37), 9888-9896 (2014-09-15)
    Though growth factors allow tissue regeneration, the trade-off between their effectiveness and adverse effects limits clinical application. The key issues in current growth factor therapy largely derive from initial burst pharmacokinetics, rapid clearance, and proteolytic cleavage resulting in clinical ineffectiveness
    View All Related Papers

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