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Key Documents

Safety Information

SRP6053

Sigma-Aldrich

ProBDNF human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

Synonym(s):

Abrineurin, BDNF, Brain-derived neurotrophic factor

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
To inquire about this product SRP6053, please contact your local Merck office or dealer. Contact Technical Service

biological source

human

recombinant

expressed in E. coli

Assay

≥95% (HPLC)
≥95% (SDS-PAGE)

form

lyophilized

mol wt

~52 kDa

packaging

pkg of 10 μg

NCBI accession no.

P23560

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... BDNF(627)

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sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

sterility

non-sterile

material

turquoise

material

turquoise

material

red

material

-

packaging

pack of 200 ea (2 bags × 100 tips)

packaging

pack of 200 ea (2 bags × 100 tips)

packaging

pack of 500 ea (5 bags × 100 tips)

packaging

pack of 500 ea (5 bags × 100 tips)

availability

available only in (India)

availability

available only in (India)

availability

available only in (India)

availability

available only in (India)

capacity

1-10 mL

capacity

0.5-10 mL

capacity

500-2500 μL

capacity

100-5000 μL

General description

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors.[1][2] The precursor form of brain-derived neurotrophic factor (pro-BDNF) undergoes post-translational cleavage to form mature BDNF (mBDNF). The gene encoding this protein is localized on human chromosome 11p14.1.[3][4]

Biochem/physiol Actions

Precursor form of brain-derived neurotrophic factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) (2) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the tropomyosin-related kinase B (TrkB) kinase receptor and promotes the survival, growth and differentiation of neurons.[1] As proneurotrophins and mature neurotrophins elicit opposite biological effects, pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.

Physical form

Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 250 mM NaCl, pH 7.2.

Preparation Note

Centrifuge the vial prior to opening.

Reconstitution

Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/mL.). This can further be diluted to other aqueous buffers.

Other Notes

Recombinant Human precursor form of Brain-derived neurotrophic factor produced in E. coli is a non-glycosylated polypeptide chain containing 2X229 amino acids as a homodimer and having a molecular mass of 52 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Pro-Met-Lys-Glu.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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Certificates of Analysis (COA)

Lot/Batch Number
7K014273
7K194273

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The presence of a single-nucleotide polymorphism in the BDNF gene affects the rate of locomotor adaptation after stroke.
Helm EE
Experimental Brain Research. Experimentelle Hirnforschung. Experimentation Cerebrale, 234(2), 341-351 (2016)
11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Shinawi M
American Journal of Medical Genetics. Part A, 155A(6), 1272-1280 (2011)
Function and evolution in the NGF family and its receptors.
Ebendal T
Journal of Neuroscience Research, 32(4), 461-470 (1992)
Hao-Yun Zhang et al.
Biochimica et biophysica acta, 1843(12), 2967-2975 (2014-09-23)
Iron accumulation is observed in the substantia nigra of patients with Parkinson's disease. However, it is unknown whether neurotrophic factors, brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) participate in the modulation of neuronal iron metabolism. Here
Chih-Yang Lin et al.
Biochemical pharmacology, 91(4), 522-533 (2014-08-26)
Chondrosarcomas are a type of primary malignant bone cancer, with a potent capacity for local invasion and distant metastasis. Brain-derived neurotrophic factor (BDNF) is commonly upregulated during neurogenesis. The aim of the present study was to examine the mechanism involved
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