SRP3080
IL-17 human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(s):
CTLA-8, IL-17
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
31.0 kDa
packaging
pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
color
off-white to yellow
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL17A(3605)
Related Categories
General description
The gene IL17A (interleukin 17A), also referred to as IL-17, is mapped to human chromosome 6p12.2. The gene contain three exons and encodes a proinflammatory cytokine produced by activated T cells.
Biochem/physiol Actions
The cytokine interleukin 17A is involved in the activation of proinflammatory cytokines, chemokines, and cell adhesion molecules in several cell types such as, macrophages, dendritic cells, T cells, synovial cells, and endothelial cells. Overexpression of this protein has been associated with rheumatoid arthritis, systemic lupus erythematosus, Behcet′s disease, allograft rejection, nephritic syndrome, asthma, and multiple sclerosis. In mice, it has been observed to be implicated in the development of allergic and autoimmune diseases. Polymorphism in IL17A gene has been associated with lung cancer.
Sequence
MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Physical form
Lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Interleukin-17A and -17F genes polymorphisms in lung cancer.
Kaabachi W
Cytokine, 66, 23-29 (2014)
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis.
Komiyama Y
Journal of Immunology, 177, 566-573 (2006)
Hye-Lin Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(33), E3422-E3431 (2014-08-06)
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T A Moseley et al.
Cytokine & growth factor reviews, 14(2), 155-174 (2003-03-26)
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human
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