SRP2091
FGF-1 human
recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
Synonym(s):
AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.26
biological source
human
recombinant
expressed in insect cells
Assay
≥85% (SDS-PAGE)
form
frozen liquid
mol wt
~19.2 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
500 μg/mL
color
colorless to clear
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FGF1(2246)
Related Categories
General description
The gene FGF1 (fibroblast growth factor 1) encodes a member of the fibroblast growth factor (FGF) family. It encodes a pro-angiogenic protein that is ubiquitously expressed and is secreted via transmembrane translocation from the cells through a nonclassical secretory pathway in response to stress. It has the ability to permeate membranes composed of acidic phospholipids.
Application
FGF-1 (fibroblast growth factor 1) has been used as a growth factor to study the effect of FGF1 on early branching events in isolated endoderm obtained from embryonic mouse lung. It has also been used to study the neuroprotection effect of FGF1 on cerebellar granule neurons obtained from rats.
Biochem/physiol Actions
Acidic fibroblast growth factor (FGF-1) and basic fibroblast growth factor (FGF-2) are ubiquitous cytokines found in many tissues. They have effects on multiple cell types derived from mesoderm and neuroectoderm, including endothelial cells. FGF proteins are small peptides of 155 to 268 amino acid residues. The degree of sequence identity between different family members is 30-60 % in a "central domain" of approx. 120 amino acids. This domain confers to FGFs a common tertiary structure and the ability to bind to heparin. Secreted FGFs signal to target cells by binding and activating cell-surface tyrosine kinase FGF receptors (FGFRs; 6, 7). The function of FGFs and FGFRs during embryonic development and adult physiology has been addressed by gain- and loss-of-function experiments in several animal model organisms. These studies have shown that FGFs act as key regulators of developmental events.
The protein fibroblast growth factor 1, functions intracellularly to protect cells against stress. The protein functions as an angiogenic factor that participates in tissue repair, carcinogenesis, and maintenance of vasculature stability. Its expression is found to be upregulated in in patients with rheumatic arthritis. It serves as a prognostic biomarker in several cancers and a potential therapeutic target for patients with non-small cell lung cancer.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Folding of Fibroblast Growth Factor 1 Is Critical for Its Nonclassical Release.
Prudovsky I
Biochemistry, 55, 1159-1167 (2016)
Juan Li et al.
Human pathology, 46(12), 1821-1828 (2015-09-24)
Fibroblast growth factor (FGF) 1 is identified as a candidate cancer biomarker in several kinds of cancer. However, little is known about its expression and function in non-small cell lung cancer (NSCLC). The aim of this study is to identify
Upregulation of fibroblast growth factor 1 in the synovial membranes of patients with late stage osteoarthritis.
Li R
Genetics and molecular research : GMR, 14, 11191-11199 (2015)
Rebecca L Miller et al.
Nature communications, 11(1), 1481-1481 (2020-03-22)
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date. Here, we develop a "Shotgun" Ion
Minh Bao Huynh et al.
PloS one, 14(1), e0209573-e0209573 (2019-01-05)
Glycosaminoglycans (GAGs), including heparan sulfates and chondroitin sulfates, are major components of the extracellular matrix. Upon interacting with heparin binding growth factors (HBGF), GAGs participate to the maintaintenance of tissue homeostasis and contribute to self-healing. Although several processes regulated by
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