SRP2036
BRG1, wild type human
recombinant, expressed in insect cells, ≥80% (SDS-PAGE)
Synonym(s):
BAF190, BRG1, FLJ39786, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SWI2, hSNF2b
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.26
biological source
human
recombinant
expressed in insect cells
Assay
≥80% (SDS-PAGE)
form
frozen liquid
mol wt
~185 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
300 μg/mL
color
clear
colorless
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... SMARCA4(6597)
Biochem/physiol Actions
The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation. BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Although Brg1 is involved in chromatin remodeling as a complex with other SWI/SNF proteins, purified BRG1 itself is capable of remodeling mono-nucleosomes and nucleosomal arrays in vitro. Mutations of Brg1 have been found in multiple tumor cell lines.
Physical form
Clear and colorless frozen liquid solution
Preparation Note
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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S Sif et al.
Genes & development, 12(18), 2842-2851 (1998-09-23)
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown
P A Khavari et al.
Nature, 366(6451), 170-174 (1993-11-11)
Sequence-specific DNA binding activators of gene transcription may be assisted by SWI2 (SNF2), which contains a DNA-dependent ATPase domain. We have isolated a human complementary DNA encoding a 205K nuclear protein, BRG1, that contains extensive homology to SWI2 and Drosophila
C J Fryer et al.
Nature, 393(6680), 88-91 (1998-05-20)
The assembly of transcriptional regulatory DNA sequences into chromatin plays a fundamental role in modulating gene expression. The promoter of the mouse mammary-tumour virus (MMTV) is packaged into a regular array of nucleosomes when it becomes stably integrated into mammalian
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