SRP0338
ZAP70 active human
recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)
Synonym(s):
SRK, STD, TZK, zeta-chain (TCR) associated protein kinase 70 kDa
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥50% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in baculovirus infected Sf9 cells
biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
assay
≥50% (SDS-PAGE)
form
aqueous solution
mol wt
96 kDa
packaging
pkg of 10 μg
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... ZAP70(7535)
General description
Recombinant full-length human ZAP70 (GenBank Accession No. NM_001079) full length with N-terminal GST-tag, MW= 96 kDa, was expressed by Baculovirus in Sf9 insect cells.
Application
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Physical form
Fomulated in 50 mM Tris-HCl, pH 7.5,150 mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Marie Pouzolles et al.
The Journal of allergy and clinical immunology, 145(2), 679-697 (2019-09-13)
Patients with T-cell immunodeficiencies are generally treated with allogeneic hematopoietic stem cell transplantation, but alternatives are needed for patients without matched donors. An innovative intrathymic gene therapy approach that directly targets the thymus might improve outcomes. We sought to determine
Kubra F Naqvi et al.
Frontiers in microbiology, 7, 362-362 (2016-04-06)
The enzymes involved in synthesizing the bacterial cell wall are attractive targets for the design of antibacterial compounds, since this pathway is essential for bacteria and is absent in animals, particularly humans. A survey of the genome of a bacterium
Mohammad Ishaq et al.
Journal of immunology (Baltimore, Md. : 1950), 179(6), 3851-3858 (2007-09-06)
We have recently shown that Zap70 is important in retinoid receptor-dependent transactivation in T lymphocytes. We report that Zap70 signaling is also essential in dexamethasone-inducible glucocorticoid receptor (GR)-mediated transactivation in T lymphocytes. Zap70-negative Jurkat T cells and cells reconstituted with
Owen M Siggs et al.
Immunity, 27(6), 912-926 (2007-12-21)
Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series
Sohye Yoon et al.
PloS one, 10(6), e0126378-e0126378 (2015-06-18)
Adaptive immunity in homeotherms depends greatly on CD4+ Th cells which release cytokines in response to specific antigen stimulation. Whilst bony fish and poikilothermic tetrapods possess cells that express TcR and CD4-related genes (that exist in two forms in teleost
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