All Photos(1)
Synonym(s):
α,α-Dimethylphenethylamine hydrochloride, α-Benzylisopropylamine hydrochloride, 1,1-Dimethyl-2-phenylethylamine hydrochloride, 2-Methyl-1-phenylpropan-2-amine hydrochloride, 2-Phenyl-tert-butylamine hydrochloride
Empirical Formula (Hill Notation):
C10H15N · HCl
CAS Number:
Molecular Weight:
185.69
EC Number:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl.CC(C)(N)Cc1ccccc1
InChI
1S/C10H15N.ClH/c1-10(2,11)8-9-6-4-3-5-7-9;/h3-7H,8,11H2,1-2H3;1H
InChI key
NCAIGTHBQTXTLR-UHFFFAOYSA-N
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Biochem/physiol Actions
Phentermine is a sympathomimetic that releases norepinephrine and epinephrine in CNS and periphery reducing hunger. Similarly to other amphetamines, phentermine potently inhibits DA and 5-HT uptake.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Mark J Ferris et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(7), 1708-1716 (2012-03-08)
The dopamine transporter (DAT) is the primary site of action for psychostimulant drugs such as cocaine, methylphenidate, and amphetamine. Our previous work demonstrated a reduced ability of cocaine to inhibit the DAT following high-dose cocaine self-administration (SA), corresponding to a
B Kalyanasundar et al.
Journal of neurophysiology, 114(1), 585-607 (2015-05-15)
Obesity is a worldwide health problem that has reached epidemic proportions. To ameliorate this problem, one approach is the use of appetite suppressants. These compounds are frequently amphetamine congeners such as diethylpropion (DEP), phentermine (PHEN), and bupropion (BUP), whose effects
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