SML1754
CTX1
≥95% (HPLC)
Synonym(s):
3,6-Diamino-9-acridinecarbonitrile, NSC 363260
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About This Item
Empirical Formula (Hill Notation):
C14H10N4
CAS Number:
Molecular Weight:
234.26
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥95% (HPLC)
form
powder
color
, faint to very dark red
solubility
DMSO: 15 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
CTX1 is a potent HdmX inhibitor that overcomes HdmX-mediated p53 repression.
CTX1 is a potent HdmX inhibitor that overcomes HdmX-mediated p53 repression. CTX1 inhibits proliferation and induces apoptosis in number of cancer cell lines. CTX1 inhibits growth of primary human AML in immunodeficient mice.
signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Inactivation of the p53 tumor suppressor by mutation or overexpression of negative regulators occurs frequently in cancer. As p53 plays a key role in regulating proliferation or apoptosis in response to DNA-damaging chemotherapies, strategies aimed at reactivating p53 are increasingly
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