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SML1504

Sigma-Aldrich

Tegaserod maleate

≥98% (HPLC)

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Synonym(s):
2-[(5-Methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide maleate
Empirical Formula (Hill Notation):
C16H23N5O · C4H4O4
CAS Number:
189188-57-6
Molecular Weight:
417.46
MDL number:
MFCD09028009
UNSPSC Code:
12352200
PubChem Substance ID:
329825925
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N=C(NCCCCC)N/N=C/C1=CNC2=C1C=C(OC)C=C2.OC(/C=C\C(O)=O)=O

InChI

1S/C16H23N5O.C4H4O4/c1-3-4-5-8-18-16(17)21-20-11-12-10-19-15-7-6-13(22-2)9-14(12)15;5-3(6)1-2-4(7)8/h6-7,9-11,19H,3-5,8H2,1-2H3,(H3,17,18,21);1-2H,(H,5,6)(H,7,8)/b20-11+;2-1-

InChI key

CPDDZSSEAVLMRY-FEQFWAPWSA-N

Gene Information

human ... HTR4(3360)

Application

Tegaserod maleate has been used to study its cytotoxic effects on human astrocytes and to study its effects as an anti-glioblastoma agent.

Biochem/physiol Actions

It stimulates neurotransmitter release from enteric nerves and regularizes gastrointestinal function. Tegaserod has been used to treat irritable bowel syndrome associated with constipation and chronic constipation.
Tegaserod is a potent full agonist at serotonin 5-HT4 receptors with an EC50 of 7 nM.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Corrado Blandizzi and Carmelo Scarpignato
Side Effects of Drugs Annual: A world-wide yearly survey of new data and trends in adverse drug reactions., 33, 741-767 (2011)
Screening of clinically-applicable drugs in patient-derived glioblastoma stem-like cells identifies amiodarone, clofazimine and triptolide as potential anti-glioma agents
Sigrid S
Combinatorial Chemistry: From Theory to Application (2015)

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