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SML0182

Sigma-Aldrich

bPiDl hydrate

≥98% (HPLC)

Synonym(s):

1,1′-(1,10-decanediyl)bis[3-methyl-pyridinium iodide (1:2) hydrate, N,N-decane-1,10-diyl-bis-3-picolinium diiodide hydrate

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About This Item

Empirical Formula (Hill Notation):
C22H34I2N2 · xH2O
CAS Number:
525596-64-9
Molecular Weight:
580.33 (anhydrous basis)
MDL number:
MFCD21608520
UNSPSC Code:
12352202
PubChem Substance ID:
329825211
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: ≥10 mg/mL

storage temp.

2-8°C

SMILES string

O.[I-].[I-].Cc1ccc[n+](CCCCCCCCCC[n+]2cccc(C)c2)c1

InChI

1S/C22H34N2.2HI.H2O/c1-21-13-11-17-23(19-21)15-9-7-5-3-4-6-8-10-16-24-18-12-14-22(2)20-24;;;/h11-14,17-20H,3-10,15-16H2,1-2H3;2*1H;1H2/q+2;;;/p-2

InChI key

ILAREMIWZYIULF-UHFFFAOYSA-L

Application

bPiDl hydrate may be used to study nicotinic receptor-mediated signaling.

Biochem/physiol Actions

bPiDI is an α6β2-specific antagonist that inhibits nicotine-evoked and endogenous dopamine release from rat striatal slices (IC50 = 150 nM, Imax = 55%). bPiDI treatment decreases nicotine self-administration, and nicotine-induced locomotor activity in rats.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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