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SML0128

Sigma-Aldrich

M30 dihydrochloride

≥98% (HPLC)

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Synonym(s):
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride
Empirical Formula (Hill Notation):
C14H14N2O · 2HCl
CAS Number:
64821-19-8
Molecular Weight:
299.20
MDL number:
MFCD20488063
UNSPSC Code:
12352200
PubChem Substance ID:
329825178
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

green-yellow

solubility

DMSO, heptane and xylene: ≥21 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12

InChI

1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H

InChI key

XJNICPXVRPOSSO-UHFFFAOYSA-N

Application

M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.

Biochem/physiol Actions

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H318

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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