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Merck
CN

SML0004

(S)-(+)-Clopidogrel hydrogensulfate

≥98% (HPLC), Selective P2Y12 antagonist, powder

Synonym(s):

(S)-(+)-Clopidogrel bisulfate, (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogensulfate, Clopidogrel Bisulphate

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About This Item

Empirical Formula (Hill Notation):
C16H16ClNO2S · H2SO4
CAS Number:
120202-66-6
Molecular Weight:
419.90
UNSPSC Code:
12352200
PubChem Substance ID:
329825081
NACRES:
NA.77
MDL number:
MFCD00876395

Key Documents

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Product Name

(S)-(+)-Clopidogrel hydrogensulfate, ≥98% (HPLC)

SMILES string

OS(O)(=O)=O.COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl

InChI key

FDEODCTUSIWGLK-RSAXXLAASA-N

InChI

1S/C16H16ClNO2S.H2O4S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;1-5(2,3)4/h2-5,7,9,15H,6,8,10H2,1H3;(H2,1,2,3,4)/t15-;/m0./s1

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +54 to +70°, c = 0.5 in methanol

color

white to tan

solubility

DMSO: ≥20 mg/mL (warmed)

originator

Bristol-Myers Squibb
Sanofi Aventis

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... P2RY12(64805)

Related Categories

Application

(S)-(+)-Clopidogrel hydrogensulfate was used as standard in HPLC-MS/MS to detect clopidogrel and its thiol derivative in human plasma.

Biochem/physiol Actions

(S)-(+)-Clopidogrel hydrogen sulfate is an antithrombotic antiplatelet agent.
(S)-(+)-Clopidogrel hydrogen sulfate is an antithrombotic antiplatelet agent. It specifically and irreversibly inhibits the Purinoceptor P2Y12 subtype which inhibits ADP-induced platelet aggregation. (S)-(+)-Clopidogrel hydrogen sulfate is the active isomer.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here.

wgk

WGK 3

pictograms

CorrosionEnvironment
GHS05,GHS09

signalword

Danger

hcodes

H314,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000457196
0000457196
0000135839
0000135838
0000089149

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Hong-Xia Wang et al.
Echocardiography (Mount Kisco, N.Y.), 32(6), 1003-1008 (2014-10-08)
This study aimed to examine the application of intravascular ultrasound (IVUS) in ST-segment elevation myocardial infarction (STEMI) patients with high thrombus burden (thrombus grade ≥3) undergoing emergency diagnosis and primary percutaneous coronary intervention. Eighty STEMI patients were enrolled and randomly
Cody J Peer et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 132-139 (2011-12-16)
A sensitive, selective, and rapid ultra-high performance liquid chromatography-tandem mass spectrometry (uHPLC-MS/MS) was developed for the simultaneous quantification of clopidogrel (Plavix(®)) and its derivatized active metabolite (CAMD) in human plasma. Derivatization of the active metabolite in blood with 2-bromo-3'-methoxy acetophenone
Ying Deng et al.
Phytotherapy research : PTR, 30(11), 1886-1892 (2016-11-05)
Ginkgo biloba extract (GBE), a traditional herbal product used worldwide as both medicine and supplement, is often supplied with clopidogrel for the treatment of cerebrovascular diseases. The aim of the current study was to explore the effect of GBE on
Chiao-Hsuan Chao et al.
PLoS pathogens, 15(4), e1007625-e1007625 (2019-04-23)
Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue
Baojun Wang et al.
BioMed research international, 2015, 932751-932751 (2015-06-20)
The objective of this study is to investigate the interaction of Panax quinquefolius saponin (PQS) and dual antiplatelets (aspirin and clopidogrel) on antiplatelet activity and vascular endothelial function in rats with acute myocardial infarction (AMI). Forty-eight male SD rats were
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P2受体：P2Y G蛋白家族概述

胞外核苷酸表面受体又称P2受体。了解更多有关 P2Y G 蛋白偶联受体、GPCR 和离子型 P2 受体（P2X 配体门控离子通道，LGIC）的信息。

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