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Key Documents

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Safety Information

SHCLND

Sigma-Aldrich

MISSION® shRNA

Purified DNA

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About This Item

UNSPSC Code:
41106609
To order shRNA please search for your gene of interest.
Order By Gene

Quality Level

200

shipped in

dry ice

storage temp.

−20°C

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This Item
PHR1167D2819L2906
环丙沙星 ≥98% (HPLC)

17850

环丙沙星

环丙沙星 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1167

环丙沙星

二氟沙星 盐酸盐

D2819

二氟沙星 盐酸盐

Lomefloxacin hydrochloride

L2906

Lomefloxacin hydrochloride

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

application(s)

environmental

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

form

powder or crystals

form

-

form

powder

form

-

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

General description

Our comprehensive shRNA product offering consists of over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes. The library is available in: gene family sets: gene collections related to specific functional classes such as kinases and ion channels; gene taget sets, sets of shRNA clones that target your favorite gene; and individual shRNA clones. Our shRNA and lentiviral manufacturing platforms utilize dedicated laboratories featuring state-of-the-art robotics, liquid handling and laboratory information management systems (LIMS) to provide superior quality and service for your RNAi research needs.
MISSION® TRC shRNA purified plasmid DNA format takes the hassle out of preparing DNA from each construct. DNA may be used directly for transient or stable transfection. Additionally these plasmids can be combined with packaging plasmids in a packaging cell line to produce lentiviral particles. 1 μg of DNA is provided for each construct in the target set.

Application

MISSION® shRNA has been used:
  • in the generation of ZO-1 (zonula occludens-1) knockdown[1]
  • to knock down LIF (leukemia inhibitory factor) expression in isogenic MCF10 model[2]
  • to knock down nuclear factor erythroid 2 like 1, in n MIN6 pancreatic β-cells[3]

Other Notes

To see protocols and application data please visit sigma.com/shrna.

Legal Information

Use of this product is subject to one or more license agreements.
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number

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    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

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    Deficiency of long isoforms of Nfe2l1 sensitizes MIN6 pancreatic beta cells to arsenite-induced cytotoxicity
    Cui Q, et al.
    Toxicology and Applied Pharmacology, 329(2), 67-74 (2017)
    Stage-specific roles of FGF2 signaling in human neural development
    Grabiec M, et al.
    Stem Cell Research, 17(2), 330-341 (2016)
    Epigenetic up-regulation of leukemia inhibitory factor (LIF) gene during the progression to breast cancer
    Shin JE, et al.
    Molecules and Cells, 31(2), 181-189 (2011)
    Eva Ramos-Fernández et al.
    Scientific reports, 11(1), 7395-7395 (2021-04-03)
    Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic neurotransmission and, through calcium signaling, generates nitric oxide (NO). Trying to unveil the molecular pathway triggering these postsynaptic effects, we found that
    Andrew R Chin et al.
    Journal of mammary gland biology and neoplasia, 23(3), 165-176 (2018-07-04)
    Extracellular vesicles (EVs) are secreted by many cell types and are increasingly investigated for their role in human diseases including cancer. Here we focus on the secretion and potential physiological function of non-pathological EVs secreted by polarized normal mammary epithelial
    View All Related Papers

    Articles

    MISSION® Lentiviral shRNA

    MISSION shRNA reduce the expression of specific target genes by targeting the specific mRNA therefore reducing the corresponding protein expression.

    Efficient Gene Silencing with MISSION® TRC shRNA

    RNAi Consortium (TRC): Collaborative effort among academic labs and biotech/pharma institutes advancing RNA interference research.

    Related Content

    shRNAs for Individual Genes

    Find shRNAs for Individual Genes. Over 150,000 pre-cloned shRNA constructs targeting more than 15,000 human and 15,000 mouse genes.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service