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Safety Information

SAB5700521

Sigma-Aldrich

Anti-Phospho-PERK-T982 antibody produced in rabbit

Synonym(s):

EIF2AK3, PEK, PERK, WRS

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

125

species reactivity

mouse, human, rat

concentration

1.67 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

Q9NZJ5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr982)

Gene Information

human ... EIF2AK3(9451)

General description

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Immunogen

A phospho specific peptide corresponding to residues surrounding T980 of human PERK.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

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WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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