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Merck
CN

SAB5700438

Anti-Phospho-POLR2A-S2 antibody produced in rabbit

Synonym(s):

POLR2, POLR2A, POLRA, Pol II, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

217
 63

species reactivity

rat, human

concentration

1.20 mg/ml

technique(s)

immunofluorescence: 1:50-1:100
immunoprecipitation (IP): 1:50-1:100
western blot: 1:1000-1:2000

UniProt accession no.

P24928

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer2)

Gene Information

human ... POLR2A(5430)

General description

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Immunogen

A phospho specific peptide corresponding to residues surrounding S2 of human POLR2A

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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