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Merck
CN

SAB5700398

Anti-Phospho-MAP2K4-S257/T261 antibody produced in rabbit

Synonym(s):

JNKK, JNKK1, MAP2K4, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

Key Documents

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biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

44
 45

species reactivity

human, rat, mouse

concentration

0.85 mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

P45985

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer257/pThr261)

Gene Information

human ... MAP2K4(6416)

General description

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.

Immunogen

A synthetic phosphorylated peptide around S257 & T261 of human MAP2K4 (NP_003001.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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