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Merck
CN

MAP2K4

mitogen-activated protein kinase kinase 4

别名:
JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
物种:
Human MAP2K4 (6416), Mouse Map2k4 (26398), Rat Map2k4 (287398), domestic cat MAP2K4 (101086432), Domestic Rabbit MAP2K4 (100344852), chicken MAP2K4 (417312), dog MAP2K4 (489508), sheep MAP2K4 (101115045), Horse MAP2K4 (100073094), domestic guinea pig Map2k4 (100733674) ...展开
UniProtKB ID:
P45985, B2R7N7, B3KYB2, D3DTS5, Q5U0B8, Q6FHX4, Q6P9H2, Q6PIE6
基因ID:
  • Human(6416) Summary: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]
  • Mouse(26398) mitogen-activated protein kinase kinase 4
  • Rat(287398) mitogen activated protein kinase kinase 4
  • domestic cat(101086432) mitogen-activated protein kinase kinase 4
  • Domestic Rabbit(100344852) mitogen-activated protein kinase kinase 4
  • chicken(417312) mitogen-activated protein kinase kinase 4
  • dog(489508) mitogen-activated protein kinase kinase 4
  • sheep(101115045) mitogen-activated protein kinase kinase 4
  • Horse(100073094) mitogen-activated protein kinase kinase 4
  • domestic guinea pig(100733674) mitogen-activated protein kinase kinase 4
  • naked mole-rat(101705822) mitogen-activated protein kinase kinase 4
  • cow(526469) mitogen-activated protein kinase kinase 4

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Antibodies

货号
说明
物种反应性
应用
SAB4502743
Anti-JNKK, C-Terminal antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
SAB4504267
Anti-phospho-SEK1/MKK4/JNKK1 (pSer257) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
HPA060074
Anti-MAP2K4 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
western blot
SAB4504533
Anti-phospho-SEK1/MKK4 (pThr261) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
SAB4502741
Anti-SEK1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot

Small Molecule - Inhibitor

货号
说明
物种
P215
PD 98,059, solid,
物种
human

Proteins

货号
说明
物种
14-377-M
MKK4/SKK1 Protein, active, 10 µg, Active, N-terminal GST tagged, murine MKK4 residues 34-end, for use in Kinase Assays.,
物种
mouse
14-378
MKK4/SKK1 Protein, inactive, 50 g, Unactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.,
物种
mouse

esiRNA

货号
说明
物种
EHU108421
MISSION® esiRNA, targeting human MAP2K4,
物种
human
EMU060031
MISSION® esiRNA, targeting mouse Map2k4,
物种
mouse