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Merck
CN

SAB5600095

Anti-Histone H3 K27M antibody, Rabbit Monoclonal

recombinant, expressed in HEK 293 cells, clone RM192, purified immunoglobulin

Synonym(s):

Anti-Histone H3 K27M, Histone H3 K27M Detection, Rabbit Anti-Histone H3 K27M

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-Histone H3 K27M antibody, Rabbit Monoclonal, recombinant, expressed in HEK 293 cells, clone RM192, purified immunoglobulin

recombinant

expressed in HEK 293 cells

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

RM192, monoclonal
recombinant monoclonal

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

ELISA: 0.5-2 μg/mL
immunocytochemistry: 0.005-0.1 μg/mL
immunohistochemistry: 0.005-0.1 μg/mL
western blot: 0.01-1 μg/mL

isotype

IgG

NCBI accession no.

8350

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

mutation (Lys27Met)

Gene Information

human ... H3C1(8350)

Biochem/physiol Actions

This antibody reacts to the Histone H3 K27M mutant. No cross reactivity with wild type Histone H3.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Immunogen

A peptide corresponding to Histone H3 K27M mutant.

Physical form

Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

Regulatory Information

常规特殊物品
含少量动物源组分生物产品
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Certificates of Analysis (COA)

Lot/Batch Number
T1203686
T0803328
S0902513
S0402200
R1201864

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Angela N Viaene et al.
Brain pathology (Zurich, Switzerland), 31(1), 45-60 (2020-07-19)
Congenital brain tumors are rare accounting for 0.5%-1.9% of all pediatric brain tumors. While different criteria have been used to classify a tumor as congenital, those diagnosed prior to 6 months of age are considered to be "probably" congenital in origin.
N Kfoury-Beaumont et al.
BMC biology, 20(1), 124-124 (2022-06-01)
Neurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations in epigenetic regulators are common in pediatric brain tumors, highlighting a potentially central role for disrupted epigenetic regulation of normal brain development in tumorigenesis.

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