SAB5600078
Anti-Integrin alpha 4 antibody, Rabbit monoclonal
recombinant, expressed in HEK 293 cells, clone RM268, purified immunoglobulin
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UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
recombinant
expressed in HEK 293 cells
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM268, monoclonal
recombinant monoclonal
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunoblotting: 1:1000-1:2000
immunohistochemistry: 1:1000-1:5000
isotype
IgG
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ITGA4(3676)
General description
Integrin subunit α4 (ITGA4) is an adhesive factor, that is part of the integrin family. The gene encoding it is localized on human chromosome 2q31.3.
Specificity
This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4).
Immunogen
Synthetic peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4)
Biochem/physiol Actions
Integrin subunit α 4 (ITGA4) has a role in bone marrow homing. It associates with the β1 integrin chain and forms the very-late-antigen-4 (VLA-4) complex. The protein also binds to vascular cell adhesion molecule-1, fibronectin and osteopontin (OPN) and modulates the activity of immature progenitors in the bone marrow. ITGA4 also aids the migration of B lymphocytes through the fibroblast barrier.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Integrin a4 is involved in the regulation of glioma-induced motility of bone marrow mesenchymal stem cells
Ma, Jiang-Chun, et al.
Oncology Reports (2015)
Role of integrin alpha4 in drug resistance of leukemia.
Shishido, Stephanie, et al.
Frontiers in Oncology (2014)
The integrins
Takada Y, et al.
Genome Biology (2007)
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