SAB5500070
Anti-CD68 antibody, Rabbit monoclonal
clone SP251, recombinant, expressed in proprietary host, affinity isolated antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP251, monoclonal
Application:
FACS, IHC
Citations:
11
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP251, monoclonal
species reactivity
human (tested)
technique(s)
flow cytometry: 1:100, immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CD68(968)
General description
CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML) (M1-M5 types), and granulocytic sarcoma.
CD68 (cluster of differentiation 68) gene is mapped to human chromosome 17p13.1. The gene codes for a glycoprotein, macrosialin. The encoded protein belongs to the family of LAMP (lysosome-associated membrane glycoproteins) proteins. Macrosialin contains a glycosylated mucin-like domain.
CD68 (cluster of differentiation 68) gene is mapped to human chromosome 17p13.1. The gene codes for a glycoprotein, macrosialin. The encoded protein belongs to the family of LAMP (lysosome-associated membrane glycoproteins) proteins. Macrosialin contains a glycosylated mucin-like domain.
Immunogen
Synthetic peptide derived from the internal region of the human CD68 protein.
Application
Monoclonal Anti-CD68 antibody from rabbit has been used for immunohistochemistry.
Biochem/physiol Actions
CD68 (cluster of differentiation 68), a scavenger receptor, significantly participates in the development of Alzheimer′s disease. CD68 serves as a prognostic marker in tumor cells. Deletion of the gene is known to cause reduction in the bone resorption capacity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Effect of silica oxide nanoparticles on liver of adult male albino rat. Light and electron microscopic study.
Shaimaa M F, et al.
The Egyptian journal of histology., 40(3) (2017)
Multiple Ets factors and interferon regulatory factor-4 modulate CD68 expression in a cell type-specific manner.
O'Reilly D, et al.
The Journal of Biological Chemistry, 278(24), 21909-21919 (2003)
CD68/macrosialin: not just a histochemical marker.
Chistiakov D A, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 97(1), 4-4 (2017)
Jan Van Slambrouck et al.
EBioMedicine, 92, 104608-104608 (2023-05-25)
SARS-CoV-2 is a single-stranded positive-sense RNA virus. Several negative-sense SARS-CoV-2 RNA species, both full-length genomic and subgenomic, are produced transiently during viral replication. Methodologies for rigorously characterising cell tropism and visualising ongoing viral replication at single-cell resolution in histological sections
Jacinta Murray et al.
Acta neuropathologica communications, 10(1), 69-69 (2022-05-08)
Microglia are implicated in Alzheimer's Disease (AD) pathogenesis. In a middle-aged cohort enriched for neuroinflammation, we asked whether microgliosis was related to neocortical amyloid beta (A[Formula: see text]) deposition and neuronal phosphorylated tau (p-tau), and whether microgliosis predicted cognition. Frontal
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