SAB5500008
Anti-Arginase-1 antibody, Rabbit monoclonal
clone SP156, recombinant, expressed in proprietary host, affinity isolated antibody
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP156, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
bovine, pig, rabbit
technique(s)
immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... ARG1(383)
General description
Arginase 1 (ARG1) gene with eight exons and seven introns, spanning 10-15 kb on genomic DNA, is localized on human chromosome 6q23.2. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney.
Arginase-1 (ARG1) catalyzes the hydrolysis of L-arginine into ornithine and urea, a critical step for the urea cycle. Defects in ARG1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia. There are several isoforms of mammalian arginase. The type I isoform, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Hepatocellular carcinoma usually shows higher protein expression of ARG1 than normal liver cells.
Immunogen
Synthetic peptide derived from the C-terminus of human arginase-1 protein.
Biochem/physiol Actions
In addition to urea cycle, arginase 1 (ARG1) is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
含少量动物源组分生物产品
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency
Martina H, et al.
Journal of inherited metabolic disease, 39(3), 331-340 (2016)
Carbon nanotube-based sensing devices for human Arginase-1 detection
Baldo S
Sensing and Bio-Sensing Research, 7, 168-173 (2016)
Tong-Fei Wu et al.
Pediatric neurology, 49(2), 119-123 (2013-07-19)
Argininemia is an autosomal recessive genetic disorder caused by hepatocyte arginase deficiency. It could be detected by blood amino acids analysis (high arginine) and confirmed by molecular diagnosis. The clinical manifestations in patients are similar to cerebral palsy so the
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service