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SAB5201187

Sigma-Aldrich

Monoclonal Anti-Lrrk2/Dardarin - Biotin antibody produced in mouse

clone S231B-34, purified immunoglobulin

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Synonym(s):
Anti-Dardarin, Anti-Leucine-rich repeat kinase 2, Anti-PARK8, Anti-RIP7
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

biotin conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S231B-34, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 200 kDa

species reactivity

human, rat

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_940980

UniProt accession no.

Q5S007

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LRRK2(120892)

General description

Leucine rich repeat kinase 2 (LRRK2) is a large protein containing protein-protein interaction region enclosing two main domains for : central kinase and GTPase.

Immunogen

Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.

Biochem/physiol Actions

Mutation in the leucine rich repeat kinase 2 (LRRK2) gene causes familial Parkinson′s disease (PD) and sporadic PD. Mitochondrial dysfunction is observed as a result of LRRK2 gene variation.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH 7.4, 50% glycerol, 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Case-control analysis of leucine-rich repeat kinase 2 protective variants in Alzheimer's disease
Ng ASL, et al.
Neurobiology of Aging, 64, 157-e7-157-e7 (2018)
LRRK2 mediated Rab8a phosphorylation promotes lipid storage
Yu M, et al.
Lipids in Health and Disease, 17(1), 34-34 (2018)
Decreased sirtuin deacetylase activity in LRRK2 G2019S iPSC-derived dopaminergic neurons
Schwab AJ, et a.
Stem Cell Reports, 9(6), 1839-1852 (2017)

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