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SAB5200222

Sigma-Aldrich

Monoclonal Anti-Kcc2 antibody produced in mouse

clone S1-12, purified immunoglobulin

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Synonym(s):
Anti-Electroneutral potassium chloride cotransporter 2, Anti-Potassium Chloride Cotransporter, Anti-SLC12A5, Anti-hKCC2
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S1-12, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 140 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NP_599190

UniProt accession no.

Q9H2X9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Slc12a5(171373)

Specificity

Detects ~140kDa.

Immunogen

Fusion protein amino acids 932-1043 corresponding to rat KCC2

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Lulan Chen et al.
Scientific reports, 7(1), 156-156 (2017-03-11)
GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl-] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models.

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