SAB4700142
Monoclonal Anti-CD80-FITC antibody produced in mouse
clone MEM-233, purified immunoglobulin, buffered aqueous solution
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Synonym(s):
Anti-B7-1
UNSPSC Code:
12352203
NACRES:
NA.44
Recommended Products
biological source
mouse
Quality Level
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MEM-233, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CD80(941)
Related Categories
General description
Cluster of differentiation 80 (CD80), also called as lymphocyte activation antigen 7-1, is encoded by the gene mapped to human chromosome 3q13.33. The encoded protein is mainly expressed on antigen presenting cells such as, neutrophils, macrophages and dendritic cells.
The antibody MEM-233 reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Immunogen
Extracellular domain of human CD80 fused to human IgG1(Fc)
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
Cluster of differentiation 80 (CD80) interacts with its ligand, co-stimulator ligand CD28 or with cytotoxic T-lymphocyte protein 4 (CTLA-4) and facilitates the regulation of CD4+ and CD8+ T cell activity. Elevated urinary CD80 excretion leads to Fabry disease. CD80, which is expressed on surface of dendritic cells acts as a key co-stimulatory molecule and induces second signal for the proper stimulation of cancer antigen-specific naive T cells.
Features and Benefits
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Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population
Tang XF
The Journal of Investigative Dermatology, 133, 403-410 (2013)
Prediction of Radix Astragali Immunomodulatory Effect of CD80 Expression from Chromatograms by Quantitative Pattern-Activity Relationship.
Ng MC
BioMed Research International (2017)
Increased urinary CD80 excretion and podocyturia in Fabry disease
Trimarchi H
Journal of Translational Medicine, 14 (2016)
Raquel Gil-Edo et al.
Pharmaceuticals (Basel, Switzerland), 16(6) (2023-06-28)
This work focuses on the development of thirteen benzylethylenearyl ureas and one carbamate. After the synthesis and purification of the compounds, we studied their antiproliferative action on cell lines, such as HEK-293, and cancer ones, such as HT-29, MCF-7 or
Exploring BenzylethoxyAryl Urea Scaffolds for Multitarget Immunomodulation Therapies.
Gil-Edo, et al.
International Journal of Molecular Sciences, 24 (2023)
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