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Key Documents

Safety Information

SAB4504574

Sigma-Aldrich

Anti-phospho-Caspase 8 (pTyr380) antibody produced in rabbit

affinity isolated antibody

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100 μG
CN¥3,630.00

CN¥3,630.00

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100 μG
CN¥3,630.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CN¥3,630.00

Please contact Customer Service for Availability

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 55 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

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Anti-phospho-Caspase 8 (pTyr380) antibody produced in rabbit affinity isolated antibody

SAB4504574

Anti-phospho-Caspase 8 (pTyr380) antibody produced in rabbit

Anti-Caspase-8 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

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Anti-Caspase 9 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

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Anti-Caspase 9 antibody produced in rabbit

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

mouse

biological source

rabbit

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

UniProt accession no.

Q14790

UniProt accession no.

Q14790

UniProt accession no.

Q14790

UniProt accession no.

P55211

General description

Caspase-8 (CASP8) is a member of the cysteine aspartate-specific proteases family. It is produced in the cell as procaspase-8, a sluggish zymogen. Procaspase-8 has a long prodomain, carrying two major protein interaction domains, DED1 and DED2, followed by one large (p18) and one small (p10) catalytic subunit. CASP8 is mapped to human chromosome 2q33.

Immunogen

The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.

Immunogen Range: 346-395

Biochem/physiol Actions

Caspase-8 (CASP8) is involved in apoptosis, inflammation and cellular differentiation. It activates programmed cell death, after death receptor ligation. Casp8 is essential for the clonal expansion of T and B cell. It also participates in lymphocyte homeostasis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Certificates of Analysis (COA)

    Lot/Batch Number
    118011

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    Find documentation for the products that you have recently purchased in the Document Library.

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    Functions of Caspase 8: the Identified and the Mysterious.
    Guy SS and Craig MW
    Seminars in Immunology, 26(3), 246?252-246?252 (2014)
    Structure and chromosome localization of the human CASP8 gene.
    Jose GA, et al.
    Gene, 226(2), 225-232 (1999)
    Caspase-8, association with Alzheimer?s Disease and functional analysis of rare variants.
    Jan R, et al.
    PLoS ONE, 12(10), e0185777-e0185777 (2017)
    Dwayne G Stupack
    Cancer letters, 332(2), 133-140 (2010-09-08)
    Caspase-8 is an apical caspase which initiates programmed cell death following death receptor ligation. This central role in apoptosis has prompted significant clinical interest in regulating caspase-8 expression and proteolytic activity. However, caspase-8 has also been found to play a

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