SAB4504476
Anti-phospho-mTOR (pSer2448) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 288 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer2448)
Gene Information
human ... MTOR(2475)
Related Categories
General description
The mechanistic/mammalian target of rapamycin (mTOR) is a serine/threonine kinase. It is a member of the phosphatidylinositide 3-kinases (PI 3-kinases or PI3Ks) family. It is mapped to human chromosome 1p36.22.
Immunogen
The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Ser2448.
Immunogen Range: 2415-2464
Immunogen Range: 2415-2464
Application
Anti-phospho-mTOR (pSer2448) antibody has been used in western blotting.
Biochem/physiol Actions
The mechanistic/mammalian target of rapamycin (mTOR) controls protein translation, cell growth, survival, invasion and metabolism. It acts as an intracellular signalling regulator, which links the extracellular events to the intracellular process. mTOR also acts on the protein synthesis machinery.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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recommended
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Cap-independent translation ensures mTOR expression and function upon protein synthesis inhibition
Marques-Ramos A, et al.
RNA, rna-063040 (2017)
Jie Yuan et al.
International journal of molecular medicine, 41(4), 2086-2098 (2018-01-19)
Presbycusis is the most common sensory impairment associated with aging; however, the underlying molecular mechanism remains unclear. Autophagy has been demonstrated to serve a key role in diverse diseases; however, no studies have examined its function in central presbycusis. The
Expression of the mTOR pathway regulators in human pituitary adenomas indicates the clinical course
Jia W, et al.
Anticancer Research, 33(8), 3123-3131 (2013)
Autophagy regulates the degeneration of the auditory cortex through the AMPK-mTOR-ULK1 signaling pathway
Yuan J, et al.
International Journal of Molecular Medicine, 41(4), 2086-2098 (2018)
Yulin Zhao et al.
Aging, 13(18), 22459-22473 (2021-09-24)
Emerging studies have revealed that non-coding RNAs contribute to regulating intervertebral disc degeneration (IVDD). Here, we intended to probe into the function of miR-19b-3p in IVDD evolvement. The miR-19b-3p level in the intervertebral disc (IVD) tissues of IVDD patients and
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