SAB4504403
Anti-phospho-FAK (pTyr397) antibody produced in rabbit
affinity isolated antibody
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All Photos(6)
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 119 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr397)
Gene Information
human ... PTK2(5747)
General description
Protein tyrosine kinase 2 (PTK2), also known as FAK (focal adhesion kinase), is encoded by the gene mapped to human chromosome 8q24-qter. The encoded protein is localized to cell adhesion sites and extracellular matrix.
Immunogen
The antiserum was produced against synthesized peptide derived from human FAK around the phosphorylation site of Tyr397.
Immunogen Range: 364-413
Immunogen Range: 364-413
Biochem/physiol Actions
Protein tyrosine kinase 2 (PTK2) is a non-receptor tyrosine kinase which is known to regulate cell migration, proliferation, cell survival and invasiveness. Increased expression of FAK (focal adhesion kinase) leads to metastatic breast tumors and lung cancer. Inhibition of FAK tyrosine kinase activity stops various cellular process necessary for tumor growth. Hence, FAK inhibitors are considered to be potential therapeutic methods for cancer treatment. FAK is one of the important components of integrin adhesion complexes (IACs)and it plays a vital role in maintaining IAC dynamics. Cell interactions with components of extracellular matrix and a number of agonists, such as neuropeptides, activate Ptk2. Ptk2, mediates cell signaling through its kinase dependent/independent functions. Upregulation of the gene is observed in hepatocellular carcinoma, which is accompanied with portal venous invasion and intrahepatic metastasis.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Iliet Payan et al.
International journal of oncology, 48(5), 2043-2054 (2016-03-18)
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase known to promote cell migration and invasiveness. Overexpression and increased activity of FAK are closely associated with metastatic breast tumors and are linked to poor prognosis. This study discovered an inverse
Focal adhesion kinase depletion reduces human hepatocellular carcinoma growth by repressing enhancer of zeste homolog 2.
Gnani D, et al.
Cell Death and Differentiation, 24(5), 889-889 (2017)
MicroRNA-7 inhibits cell proliferation, migration and invasion in human non-small cell lung cancer cells by targeting FAK through ERK/MAPK signaling pathway.
Cao Q, et al.
Oncotarget, 7(47), 77468-77468 (2016)
T Konry et al.
Talanta, 75(2), 564-571 (2008-03-29)
We present herein an effective and versatile method to fabricate a micro-patterned structure of conductive polymer, poly(pyrrole-benzophenone), on Indium Tin Oxide (ITO) glass chips for the subsequent photo-immobilization of various bioreceptor, antigens. Such methodologies are based on photolithography of ITO
Focal adhesion kinase inhibitors in combination with erlotinib demonstrate enhanced anti-tumor activity in non-small cell lung cancer.
Howe G A, et al.
PLoS ONE, 11(3), e0150567-e0150567 (2016)
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