SAB4504172
Anti-phospho-EPHB1/2 (pTyr594/604) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 109 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr594/pTyr604)
Gene Information
human ... EPHA2(1969), EPHB1(2047)
General description
EPHB1(ephrin type-B receptor 1) and EPHA2 (EPH receptor A2) belongs to the Eph gene family of receptor tyrosine kinases. EPHB1 is present in venous endothelial cells during embryonic development to adulthood. It is located on human chromosome 3q22.2. EPH receptor A2 codes for a 976 amino acid, type-1 transmembrane protein with extracellular NH2-terminal and cytoplasmic COOH-terminal halves.
Immunogen
The antiserum was produced against synthesized peptide derived from human EPHB1/2 around the phosphorylation site of Tyr594/604.
Immunogen Range: 561-610
Immunogen Range: 561-610
Biochem/physiol Actions
EPHB1(ephrin type-B receptor 1) participates in carcinogenesis of RCC (renal cell carcinoma). EPHB1 plays a major role in the growth of nervous and vascular systems. It acts as a biomarker for squamous cell/adenosquamous carcinomas and adenocarcinomas of the gallbladder. EPHA2 (EPH receptor A2) gene is associated with cataracts.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Decreased expression of receptor tyrosine kinase of EphB1 protein in renal cell carcinomas
Zhou S, et al.
International Journal of Clinical and Experimental Pathology, 7(7), 4254-4260 (2014)
Loss of expression of EphB1 protein in serous carcinoma of ovary associated with metastasis and poor survival
Wang H, et al.
International Journal of Clinical and Experimental Pathology, 7(1), 313-321 (2013)
The EPHA2 gene is associated with cataracts linked to chromosome 1p
Shiels A, et al.
Molecular Vision, 14, 2042-2055 (2008)
EphB1 and Ephrin-B, new potential biomarkers for squamous cell/adenosquamous carcinomas and adenocarcinomas of the gallbladder
Yuan Y, et al.
Asian Pacific Journal of Cancer Prevention, 15(3), 1441-1446 (2014)
Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival
Lake SL, et al.
The American Journal of Pathology, 182(3), 678-687 (2013)
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