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SAB4503970

Anti-phospho-PLB (pSer16+Thr17) antibody produced in rabbit

affinity isolated antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunofluorescence
Species reactivity:
human, rat, mouse
Citations:
4
Technique(s):
ELISA: 1:1000
immunofluorescence: 1:100-1:500
Uniprot accession no.:
P26678

Key Documents

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Product Name

Anti-phospho-PLB (pSer16+Thr17) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 6 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500

NCBI accession no.

P26678

UniProt accession no.

P26678

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer16/pThr17)

Quality Level

100

Gene Information

human ... PLN(5350)

Related Categories

Biochem/physiol Actions

Phospholamban (PLN) participates in calcium signalling and muscle contraction. This protein regulates the activity of the sarcoplasmic reticulum Ca2+-ATPase (SERCA) of cardiac myocytes. Mutations in the phospholamban (PLN) gene result in dilated cardiomyopathy (DCM) and severe heart failure.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Phospholamban (PLN) gene codes for a small integral membrane protein. It is located on human chromosome 6q22.1. PLN is a 52-amino-acid phosphoprotein.

Immunogen

The antiserum was produced against synthesized peptide derived from human PLB around the phosphorylation site of Ser16 and Thr17.

Immunogen Range: 1-50

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
110550

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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
Haghighi K, et al.
The Journal of Clinical Investigation, 111(6), 869-876 (2003)
Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
Smeazzetto S, et al.
Physical Chemistry Chemical Physics, 18(3), 1629-1636 (2016)
Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.
Fish M, et al.
Scientific Reports, 6, 22235-22235 (2016)
Diagnostic, prognostic, and therapeutic implications of genetic testing for hypertrophic cardiomyopathy.
Bos J M, et al.
Journal of the American College of Cardiology, 54(3), 201-211 (2009)

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