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Safety Information

SAB4503819

Sigma-Aldrich

Anti-phospho-Filamin A (pSer2152) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-ABP-280, Anti-ABPX, Anti-CSBS, Anti-CVD1, Anti-FGS2, Anti-FLN, Anti-FLN-A, Anti-FMD, Anti-NHBP, Anti-OPD, Anti-OPD1, Anti-OPD2, Anti-XLVD, Anti-XMVD

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 280 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P21333

UniProt accession no.

P21333

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... FLNA(2316)

General description

Filamin A (FLNA) is an X-linked, ubiquitous actin-binding protein. It is a 280kDa protein consisting of two N-terminal calponin homology domains and a long C-terminal rod-like domain. FLNA is mapped to human chromosome Xq28.

Immunogen

The antiserum was produced against synthesized peptide derived from human Filamin A around the phosphorylation site of Ser2152.

Immunogen Range: 2121-2170

Biochem/physiol Actions

Filamin A (FLNA) has the ability to stop or induce the growth and development of cancer. It regulates the gene transcription of RNA polymerase III in transformed cell lines. In males, mutation in filamin A (FLNA) results in Ehlers-Danlos syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
110072

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Cytoskeletal Filamin A Differentially Modulates RNA Polymerase III Gene Transcription in Transformed Cell Lines
Wang J, et al.
The Journal of Biological Chemistry, 291(48), 25239-25246 (2016)
Abnormal development of the human cerebral cortex: genetics, functional consequences and treatment options
Guerrini R, et al.
Trends in Neurosciences, 31(3), 154-162 (2008)
Ehlers-Danlos syndrome with lethal cardiac valvular dystrophy in males carrying a novel splice mutation in FLNA
Ritelli M, et al.
American Journal of Medical Genetics. Part A, 173(1), 169-176 (2017)

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