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SAB4503757

Sigma-Aldrich

Anti-phospho-CREB (pSer142) antibody produced in rabbit

affinity isolated antibody

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UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P16220

UniProt accession no.

P16220

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer142)

Gene Information

human ... CREB1(1385)

General description

CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. CREB1 is upregulated abundantly in human tissues and is located on human chromosome 2q33–35.

Immunogen

The antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser142.

Immunogen Range: 111-160

Biochem/physiol Actions

Knockdown of CREB (cAMP response element-binding protein) promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress
Zubenko GS and Hughes HB 3rd
Molecular Psychiatry, 14(4), 390-397 (2009)
Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction
Qiu YY, et al.
Genetics and molecular research : GMR (2016)
CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals
Shabestari RM, et al.
Biomedicine and Pharmacotherapy, 87, 274-279 (2017)
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
Pregi N, et al.
Molecular and Cellular Biochemistry, 425(1-2), 9-24 (2017)
Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo
Francois S, et al.
Journal of Virology, 90(19), 8686-8697 (2016)

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