SAB4503751
Anti-E-cadherin antibody produced in rabbit
affinity isolated antibody
Synonym(s):
CAM 120/80, CD324, Cadherin-1, Epithelial cadherin, Uvomorulin
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 97 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CDH1(999)
General description
Anti-E-cadherin Antibody detects endogenous levels of total E-cadherin protein.
CDH1 (cadherin 1) codes for a transmembrane glycoprotein E-cadherin that is located on human chromosome 16q22.1. It is a tumor suppressor gene, which is also known as Cdh1p/Hct1p, Fizzy-related, Ste9, or Srw1.
Immunogen
The antiserum was produced against synthesized peptide derived from human E-cadherin.
Immunogen Range: 1-50
Immunogen Range: 1-50
Application
Anti-E-cadherin, N-Terminal antibody has been used in protein extraction,western blotting, confocal fluorescence microscopy analysis, immunostaining and co-immunoprecipitation.
Biochem/physiol Actions
CDH1 (cadherin 1) helps to conserve the homophilic cell-cell adhesion in epithelial tissues. Inadequate expression of CDH1 results in colon cancer and renal cell carcinoma (RCC).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/?-catenin and MAPK signalling
Gu Y, et al.
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Junji Itou et al.
FEBS letters, 587(18), 3115-3121 (2013-08-21)
In cell cultures, the dispersed phenotype is indicative of the migratory ability. Here we characterized Sal-like 4 (SALL4) as a dispersion factor in basal-like breast cancer. Our shRNA-mediated SALL4 knockdown system and SALL4 overexpression system revealed that SALL4 suppresses the
Sal-like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal-like breast cancer
Itou J, et al.
Febs Letters, 587(18), 3115-3121 (2013)
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