SAB4503192
Anti-SLC24A6, C-Terminal antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
NCKX6, Na(+)/K(+)/Ca(2+)-exchange protein 6, SLC24A6, Sodium/potassium/calcium exchanger 6, Solute carrier family 24 member 6
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 64 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC24A6(80024)
General description
The SLC24A6 (solute carrier family 8 member B1) gene is mapped to human chromosome 12q24.13. The gene codes for a K+-dependent Na+/Ca2+ exchanger. The encoded protein is ubiquitously expressed in all the tissues. It is localized to inner mitochondrial membrane.
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC24A6.
Immunogen Range: 494-543
Immunogen Range: 494-543
Biochem/physiol Actions
SLC24A6 (solute carrier family 8 member B1) protein is responsible for maintaining Ca2+ homeostasis in the cell. SLC24A6 protein regulates sodium uptake and calcium efflux from the mitochondria.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Molecular cloning of a sixth member of the K+-dependent Na+/Ca2+ exchanger gene family, NCKX6.
Cai X, et al.
The Journal of Biological Chemistry, 279(7), 5867- 5876 (2004)
NCLX Protein, but Not LETM1, Mediates Mitochondrial Ca2+ Extrusion, Thereby Limiting Ca2+-induced NAD(P)H Production and Modulating Matrix Redox State*
De Marchi U, et al.
The Journal of Biological Chemistry, 289(29), 20377-20385 (2014)
Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.
Nita I I, et al.
Biochimica et Biophysica Acta, 1863(12), 2868-2880 (2016)
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