SAB4503183
Anti-TUSC3 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
N33, Protein N33, TUSC3, Tumor suppressor candidate 3
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 39 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TUSC3(7991)
General description
Tumor suppressor candidate 3 (TUSC3) codes for a subunit of the endoplasmic reticulum-bound oligosaccharyltransferase complex. It is a 348 amino acid protein, that has 11 exons spanning ∼224 Kbp of the genomic DNA. TUSC3 has five potential transmembrane domains and is located on human chromosome 8p22.
Immunogen
The antiserum was produced against synthesized peptide derived from human TUSC3.
Immunogen Range: 131-180
Immunogen Range: 131-180
Application
Anti-TUSC3 antibody has been used in immunohistochemistry, immunoblotting and co-immunoprecipitation.
Biochem/physiol Actions
Tumor suppressor candidate 3 (TUSC3) is a tumor suppressor gene, that is responsible for autosomal recessive mental retardation. It participates in catalyzing the transfer of a 14-sugar oligosaccharide from dolichol to nascent protein. Absence of TUSC3 is associated with lymph node metastasis in larynx and pharynx squamous cell carcinomas.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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A defect in the TUSC3 gene is associated with autosomal recessive mental retardation
Garshasbi M, et al.
American Journal of Human Genetics, 82(5), 1158-1164 (2008)
Oncogenic function of TUSC3 in non-small cell lung cancer is associated with Hedgehog signalling pathway
Gu Y, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(7), 1749-1760 (2017)
Ahmed Magzoub Khalid et al.
Bioscience, biotechnology, and biochemistry, 77(10), 2019-2024 (2013-10-08)
Analysis of microarray data obtained by comparing gene expression between 2-week-old infant and 7-week-old mature SD rat testes revealed novel targets involved in tumor suppression. Reverse-transcription polymerase chain reaction and Northern blotting indicated that Tusc3 gene expression was upregulated in
Shoujie Wang et al.
Cell biochemistry and function, 38(5), 604-612 (2020-02-25)
Melanoma is a highly malignant and is a life-threatening disease with no effective treatment currently. This study aims to evaluate the significance of TUSC3, an endoplasmic reticulum stress (ERS)-inducible gene and explore its relationship with AKT/GSK3-β/β-catenin signalling pathway in melanoma
David L Lin et al.
mBio, 8(4) (2017-07-20)
Dengue virus (DENV) is the most common arboviral infection globally, infecting an estimated 390 million people each year. We employed a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen to identify host dependency factors required for DENV propagation and
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