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SAB4503171

Anti-FZD3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

FZD3, Frizzled-3, Fz-3, hFz3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD06798445

Key Documents

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Product Name

Anti-FZD3 antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 76 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBI accession no.

Q9NPG1

UniProt accession no.

Q9NPG1

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FZD3(7976)

Related Categories

Biochem/physiol Actions

Mutation in FZD3 (frizzled class receptor 3) gene might account for Hirschsprung disease, a birth defect lacking the intrinsic ganglion cells of the lower intestine. FZD3 regulates the growth of longitudinal axon tracts in the central nervous system. FZD3 mediates the dynamics of axon within the enteric, sympathetic and peripheral nervous systems. FZD3 regulates planar cell polarity. Abnomal FZD3 gene methylation causes chromatin structure modifications, associated with congenital hydrocephalus.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-FZD3 Antibody detects endogenous levels of total FZD3 protein.
The FZD3 (frizzled class receptor 3) gene is mapped to human chromosome 8p21.1. It codes for a receptor with seven-transmembrane domain and is expressed in human melanocytes.

Immunogen

The antiserum was produced against synthesized peptide derived from human FZD3.

Immunogen Range: 481-530

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
61257

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Celsr3 and Fzd3 in axon guidance.
Chai G, et al.
The International Journal of Biochemistry & Cell Biology, 64, 11-14 (2015)
Genotype?Phenotype Association Studies of Chromosome 8p Inverted Duplication Deletion Syndrome
Fisch GS, et al.
Behavior Genetics, 41(3), 373-380 (2011)
The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines.
Chang CH, et al.
Journal of Dermatological Science, 75(2), 100-108 (2014)
Impaired methylation modifications of FZD3 alter chromatin accessibility and are involved in congenital hydrocephalus pathogenesis.
Wang L, et al.
Brain Research, 1569, 48-56 (2014)
Deregulation of the planar cell polarity genes CELSR3 and FZD3 in Hirschsprung disease.
Su L
Experimental and Molecular Pathology, 101(2), 241-248 (2016)

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