SAB4503170
Anti-FZD3 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
FZD3, Frizzled-3, Fz-3, hFz3
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 76 kDa
species reactivity
mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FZD3(7976)
General description
Anti-FZD3 Antibody detects endogenous levels of total FZD3 protein.
The FZD3 (frizzled class receptor 3) gene is mapped to human chromosome 8p21.1. It codes for a receptor with seven-transmembrane domain and is expressed in human melanocytes.
Immunogen
The antiserum was produced against synthesized peptide derived from human FZD3.
Immunogen Range: 141-190
Immunogen Range: 141-190
Application
Anti-FZD3 antibody produced in rabbit has been used in immunohistochemistry.
Biochem/physiol Actions
Mutation in FZD3 (frizzled class receptor 3) gene might account for Hirschsprung disease, a birth defect lacking the intrinsic ganglion cells of the lower intestine. FZD3 regulates the growth of longitudinal axon tracts in the central nervous system. FZD3 mediates the dynamics of axon within the enteric, sympathetic and peripheral nervous systems. FZD3 regulates planar cell polarity. Abnomal FZD3 gene methylation causes chromatin structure modifications, associated with congenital hydrocephalus.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Jie Xie et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 66, 24-32 (2017-12-03)
Previous studies have demonstrated that both Wnt5a and Sonic hedgehog (Shh) are involved in regulating the pathfinding of descending serotonergic (5-HT, 5-hydroxytryptamine) axons in an opposite manner in the brainstem. Shh and Wnt signaling pathways interact to guide post-crossing commissural
The roles of Frizzled-3 and Wnt3a on melanocyte development: in vitro studies on neural crest cells and melanocyte precursor cell lines.
Chang CH, et al.
Journal of Dermatological Science, 75(2), 100-108 (2014)
Impaired methylation modifications of FZD3 alter chromatin accessibility and are involved in congenital hydrocephalus pathogenesis.
Wang L, et al.
Brain Research, 1569, 48-56 (2014)
Ateeque Siddique et al.
Canadian journal of physiology and pharmacology, 96(2), 208-214 (2017-12-16)
The cellular mechanisms that induce calcific aortic stenosis are yet to be unraveled. Wnt signaling is increasingly being considered as a major player in the disease process. However, the presence of Wnt Frizzled (Fzd) receptors and co-receptors LRP5 and 6
Celsr3 and Fzd3 in axon guidance.
Chai G, et al.
The International Journal of Biochemistry & Cell Biology, 64, 11-14 (2015)
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