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Safety Information

SAB4502971

Sigma-Aldrich

Anti-TIMP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

COLLAGENASE INHIBITOR, EPA, HCI, HUMAN, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity

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About This Item

MDL number:
MFCD01322705
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 23 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

P01033

UniProt accession no.

P01033

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TIMP1(7076)

General description

The TIMP1 (TIMP metallopeptidase inhibitor 1) gene is mapped to human chromosome Xp11.3.
Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of TIMPs protein family. It is widely expressed in most of the human tissues and body fluids. TIMP1 is a wedge shaped protein with five β-strands, a central helical region representing the interface of the two domains and a C-terminal β-structure.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIMP1.

Immunogen Range: 61-110

Application

Anti-TIMP1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

TIMP1 (TIMP metallopeptidase inhibitor 1) mediates the communication between tumor cells and cancer associated fibroblasts and contributes to tumor progression in condition such as hepatocellular carcinoma. The encoded protein is a cytokine tissue inhibitor. Timp1 regulates the activity of matrix metalloproteinases (MMP) especially MMP-8 and -9. Imbalance in Timp1 levels lowers the fibrotic material in the extracellular matrix and results in inflammation. This might contribute to the pathogenesis of myocardial fibrosis, atherosclerosis and acute coronary syndrome. Timp1 level serves as an important biomarker in the development of sepsis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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TIMPs as multifacial proteins
Lambert E, et al.
Critical Reviews in Oncology/Hematology, 49(3), 187-198 (2004)
IL-6/STAT3 axis initiated CAFs via up-regulating TIMP-1 which was attenuated by acetylation of STAT3 induced by PCAF in HCC microenvironment.
Zheng X
Cellular Signalling, 28(9), 1314-1324 (2016)
Genetic polymorphisms and plasma levels of BCL11A contribute to the development of laryngeal squamous cell carcinoma.
Zhou J
PLoS ONE, 12(2), 1-11 (2017)
Low MMP-8/TIMP-1 reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 may help to differentiate it from acute coronary syndrome.
Parkkonen O
PLoS ONE, 12(3), 1-11 (2017)
Genome-wide scan of exfoliation syndrome.
Lemmela S
Investigative Ophthalmology & Visual Science, 48(9), 4136-4142 (2007)
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