SAB4502906
Anti-Synaptophysin antibody produced in rabbit
affinity isolated antibody
Synonym(s):
major synaptic vesicle protein p38, synaptophysin
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SYP(6855)
General description
Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.
Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Synaptophysin.
Immunogen Range: 101-150
Immunogen Range: 101-150
Application
Anti-Synaptophysin antibody produced in rabbit has been used in:
- immunocytochemistry
- western blotting
- immunohistochemistry
Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.
Biochem/physiol Actions
Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Moderate maternal food restriction in mice impairs physical growth, behavior, and neurodevelopment of offspring
Akitake Y, et al.
Nutrition Research (New York, N.Y.), 35(1), 76-87 (2015)
3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice.
Yaoming Wang et al.
Nature medicine, 22(9), 1050-1055 (2016-08-23)
Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling activities mediated by the activation of protease-activated receptor 1 (F2R, also known as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage. Recombinant variants of APC
Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide
Pal SK, et al.
Urologic Oncology, 36(4), 162-e1-162-e1 (2018)
Single cell transcriptome analysis of mouse carotid body glomus cells
Zhou T, et al.
The Journal of Physiology, 594(15), 4225-4251 (2016)
Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes.
Craig IW, et al.
European Journal of Human Genetics, 12(8), 639-639 (2004)
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