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SAB4502905

Sigma-Aldrich

Anti-Synapsin, N-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Brain protein 4.1, SYN-1, synapsin I

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About This Item

MDL number:
MFCD01322679
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 74 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
western blot: 1:500-1:1000

NCBI accession no.

P17600

UniProt accession no.

P17600

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SYN1(6853)

Related Categories

General description

Anti-Synapsin Antibody detects endogenous levels of total Synapsin protein.
Synapsin I (SYN1) is a synaptic vesicle associated protein. It is present in the central nervous system like olfactory bulb, cerebral cortex, hippocampus, basal ganglia, thalamus, hypothalamus, cerebellum, pons-medulla, spinal cord and posterior pituitary gland. The protein is found in the nucleus and cytoplasm of granule cells, and in the glomerular synaptic complex of the cerebellum. SYN1 gene is located in human chromosome Xp11.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human Synapsin.

Immunogen Range: 3-52

Application

Anti-Synapsin, N-Terminal antibody has been used in immunohistochemistry.

Biochem/physiol Actions

Synapsin I (SYN1) plays an important role in neurotransmitter release, exocytosis of the synaptic vesicles, neurite elongation and synaptogenesis. Brain dysfunction occurs due to improper expression of synapsin I.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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Evidence for a Turner syndrome locus or loci at Xp11. 2-p22. 1.
Zinn AR, et al.
American Journal of Human Genetics, 63(6), 1757-1766 (1998)
A novel method to derive and expand mice neural stem cells efficiently without neuro-sphere formation.
Ma ZZ, et al.
International Journal of Clinical and Experimental Medicine, 8(8), 12834?12841-12834?12841 (2015)
Zhi-Zhao Ma et al.
International journal of clinical and experimental medicine, 8(8), 12834-12841 (2015-11-10)
Neural stem cells (NSCs) are multi-potent stem cells able to self-renew and generate immature and differentiated cell populations by asymmetric division. The NSCs are of considerable interest for cell replacement in neuro-degenerative diseases. NSCs are usually identified and expanded by
Increased synapsin I expression in cerebral malaria.
Thonsranoi K, et al.
International Journal of Clinical and Experimental Pathology, 8(11), 13996?14004-13996?14004 (2015)

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